The Binding of Isaac: Rebirth

Kill Isaac with Isaac

Have 7 or more max red hearts at one time

Hold 55 or more pennies at one time

Kill Satan with Cain

Kill Satan

Kill Satan with Judas

Beat 2 levels in a row without picking up any hearts

Beat 2 levels in a row without taking damage

Make 3 deals with the devil in one run

Kill Satan with Azazel

Have 4 or more soul hearts at one time

Kill Isaac with Lazarus

Beat the Womb for the first time

Beat the Basement 40 times

Beat the Caves 30 times

Beat the Depths 20 times

Beat the Basement/Cellar without taking damage

Beat the Boss Rush

Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball

Kill Mom

Kill Mom's Heart 3 times

Kill Mom's Heart 5 times

Kill Mom's Heart 8 times

Kill Mom's Heart 9 times

Kill Mom's Heart 10 times

Kill Mom's Heart 11 times

Kill all 7 sins