The Binding of Isaac: Repentance

Kill Isaac with Isaac

Kill Satan with Isaac

Kill Isaac with The Lost

Have 7 or more max red hearts at one time

Kill Isaac with Maggy

Kill Satan with Maggy

Hold 55 or more pennies at one time

Kill Isaac with Cain

Kill Satan with Cain

Kill Satan

Kill Isaac with Judas

Kill Satan with Judas

Beat 2 levels in a row without picking up any hearts

Kill Isaac with Eve

Kill Satan with Eve

Beat 2 levels in a row without taking damage

Kill Isaac with Samson

Kill Satan with Samson

Make 3 deals with the devil in one run

Kill Isaac with Azazel

Kill Satan with Azazel

Have 4 or more soul hearts at one time

Kill Isaac with Lazarus

Kill Satan with Lazarus

Beat the Womb for the first time

Kill Isaac with Eden

Kill Satan with Eden

Beat the Basement 40 times

Beat the Caves 30 times

Beat the Depths 20 times

Beat the Basement/Cellar without taking damage

Beat the Caves/Catacombs without taking damage

Beat the Depths/Necropolis without taking damage

Beat the Womb/Utero without taking damage

Beat the Chest or Dark Room without taking damage

Beat the Boss Rush

Beat the Dark Room

Beat the Chest

Beat the Dark Room with Isaac

Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball

Kill Mom

Kill Mom using the Bible

Kill Mom's Heart 3 times

Kill Mom's Heart 5 times

Kill Mom's Heart 8 times

Kill Mom's Heart 9 times

Kill Mom's Heart 10 times

Kill Mom's Heart 11 times

Kill Satan with ???

Kill all 7 sins

Beat Cathedral 5 times

Beat Sheol 5 times

You are the best!

Finish the game's final secret

Beat Greed Mode with Azazel

Kill ??? with Lilith

Collect all items and unlock all secrets

Beat Greedier Mode with Apollyon

Kill Hush for the first time

Kill Delirium for the first time

Beat 3 victory laps in one run

Complete ??? 3 times

Beat Hard mode as Lazarus without losing a life